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©2013 UpToDate ® Print Email Histology of the spleen in B cell prolymphocytic leukemia (A) Low power view (original magnification x20) showing replacement of the white pulp and infiltration of the red pulp. (B) High power view (original magnification x100) of the white pulp showing the typical prolymphocyte morphology with abundant cytoplasm, round nuclei, and a central eosinophilic nucleolus. This research was originally published in Blood. Dearden C. How I treat prolymphocytic leukemia. Blood 2012; 120:538. Copyright © 2012 American Society of Hematology.