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©2013 UpToDate ® Print Email BL immunohistochemistry Immunostains of MIB-1 (A), Bcl-2 (B), CD10 (C), and Bcl-6 (D) in a case of classic Burkitt lymphoma. Note that all cells are proliferating as defined by positive MIB-1 staining, except the phagocytic histiocytes in the section. CD10 is strongly expressed by the malignant cells, and Bcl-2 is negative. Note several small, reactive lymphocytes in the section staining positively for Bcl-2 that serve as an internal control. Bcl-6 staining (D) shows strong nuclear expression. Reproduced with permission from: Non-Hodgkin Lymphomas, 2nd ed, Armitage JO, Mauch PM, Harris NL, et al. (Eds), Lippincott Williams & Wilkins, Philadelphia 2010. Copyright © 2010 Lippincott Williams & Wilkins. file://www.lww.com