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©2013 UpToDate ® Print Email Bone marrow biopsy of a case of B cell acute lymphoblastic leukemia Bone marrow biopsy shows total replacement of normal hematopoietic cells with lymphoblasts that shows convoluted or folded nuclei. Hematoxylin and eosin, 100x magnification. Reproduced with permission from: Sun T. Clinical application. In: Flow Cytometry, Immunochemistry, and Molecular Genetics for Hematologic Neoplasms, 2nd ed, Lippincott Williams & Wilkins, Philadelphia 2012. Copyright © 2012 Lippincott Williams & Wilkins. file://www.lww.com