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©2013 UpToDate ® Print Email Recommendations from the United States Preventive Services Task Force on who should be offered genetic testing for BRCA mutations* For non-Ashkenazi Jewish women: Two first-degree relatives with breast cancer, one of whom was diagnosed at age 50 or younger A combination of three or more first or second-degree relatives with breast cancer regardless of age at diagnosis A combination of both breast and ovarian cancer among first and second-degree relatives A first-degree relative with bilateral breast cancer A combination of two or more first or second degree relatives with ovarian cancer, regardless of age at diagnosis A first or second-degree relative with both breast and ovarian cancer at any age History of breast cancer in a male relative For women of Ashkenazi Jewish descent: Any first-degree relative (or two second degree relatives on the same side of the family) with breast or ovarian cancer * These recommendations do not apply to women with a family history of breast or ovarian cancer that includes a relative with a known deleterious BRCA mutation. U.S. Preventive Services Task Force. Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility: recommendation statement. Ann Intern Med 2005; 143:355.