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©2013 UpToDate ® Print Email Co-infection with babesiosis and Lyme borreliosis by area and year Region Timeframe Prevalence Block Island May through September, 1990 to 1994 [1] Among 97 individuals with antibodies to B. burgdorferi identified by serosurvey, 14 percent also had antibodies to B. microti. Among 206 patients diagnosed with Lyme disease, 11 percent also experienced mild babesiosis May through September, 1997 to 2000 [2] Among 76 patients with Lyme disease, 22 percent also experienced mild babesiosis Connecticut 1986 to 1989 [3] Among 735 residents who were seropositive for B. burgdorferi, 9.5 percent also had antibodies against B. microti May through September, 1997 to 2000 [2] Among 20 patients diagnosed with Lyme disease, 50 percent also presented with symptoms of mild babesiosis Eastern Long Island 1985 [4] Among Lyme disease patients from areas endemic for both Lyme disease and babesiosis, 66 percent also had antibodies to B. microti 1988 to 2001 [5] Among 34 patients hospitalized for severe babesiosis, 53 percent were seropositive for B. burgdorferi Nantucket Island May through September, 1997 to 2000 [2] Among 65 patients diagnosed with Lyme disease, 58 percent also presented with symptoms of mild babesiosis New York State 1982 to 1991 [6] Among 136 patients diagnosed with babesiosis, 23 percent experienced clinical Lyme disease 1982 to 1993 [7] Among 139 hospitalized for severe babesiosis, 12 percent had a history of Lyme disease

Among 65 patients diagnosed with Lyme disease, 58 percent also presented with symptoms of mild babesiosis New York State 1982 to 1991 [6] Among 136 patients diagnosed with babesiosis, 23 percent experienced clinical Lyme disease 1982 to 1993 [7] Among 139 hospitalized for severe babesiosis, 12 percent had a history of Lyme disease 1. Krause, PJ, Telford, SR, 3rd, Spielman, A, et al. Concurrent Lyme disease and babesiosis. Evidence for increased severity and duration of illness. JAMA 1996; 275:1657. 2. Krause, PJ, McKay, K, Thompson, CA, et al. Disease-specific diagnosis of coinfecting tickborne zoonoses: babesiosis, human granulocytic ehrlichiosis, and Lyme disease. Clin Infect Dis 2002; 34:1184. 3. Krause, PJ, Telford SR, 3rd, Ryan, R, et al. Geographical and temporal distribution of babesial infection in Connecticut. J Clin Microbiol 1991; 29:1. 4. Benach, JL, Coleman, JL, Habicht, GS, et al. Serological evidence for simultaneous occurrences of Lyme disease and babesiosis. J Infect Dis 1985; 152:473. 5. Hatcher, JC, Greenberg, PD, Antique, J, Jimenez-Lucho, VE. Severe babesiosis in Long Island: review of 34 cases and their complications. Clin Infect Dis 2001; 32:1117. 6. Meldrum, SC, Birkhead, GS, White, DJ, et al. Human babesiosis in New York State: an epidemiological description of 136 cases. Clin Infect Dis 1992; 15:1019. 7. White, DJ, Talarico, J, Chang, HG, et al. Human babesiosis in New York State: Review of 139 hospitalized cases and analysis of prognostic factors. Arch Intern Med 1998; 158:2149.