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Exceptions: Amoxicillin; Ampicillin; Cloxacillin; Dicloxacillin; Nafcillin; Oxacillin; Penicillin G (Parenteral/Aqueous); Penicillin G Benzathine; Penicillin G Procaine; Penicillin V Potassium. Risk D: Consider therapy modification RimabotulinumtoxinB: Aminoglycosides may enhance the neuromuscular-blocking effect of RimabotulinumtoxinB. Risk C: Monitor therapy Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. Management: Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Risk D: Consider therapy modification SORAfenib: Neomycin may decrease the serum concentration of SORAfenib. Risk C: Monitor therapy Vancomycin: May enhance the nephrotoxic effect of Aminoglycosides. Risk C: Monitor therapy Vitamin K Antagonists (eg, warfarin): Neomycin may enhance the anticoagulant effect of Vitamin K Antagonists. Risk C: Monitor therapy Pregnancy Risk Factor C ( show table ) Pregnancy Implications Animal reproduction studies have not been conducted with this combination. See individual agents. Patient Information (For additional information see "Bacitracin, neomycin, and polymyxin B: Patient drug information" ) Ophthalmic: May cause sensitivity to bright light; may cause temporary blurring of vision or stinging following administration Use of UpToDate is subject to the Subscription and License Agreement . Topic 12637 Version 32.0 © 2013 UpToDate, Inc. All rights reserved. | Subscription and License Agreement | Release: 21.4 - C21.36 Licensed to: Southeast Alabama Med Ctr | Support Tag: [1102-222.190.118.195-652B83C886-S244013.14]