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Adverse Reactions Local: Anaphylactoid reactions, burning, conjunctival erythema, itching, rash, swelling Contraindications Hypersensitivity to polymyxin, bacitracin, or any component Precautions Prolonged use may result in overgrowth of nonsusceptible organisms Metabolism/Transport Effects None known. Drug Interactions (For additional information: Launch Lexi-Interact™ Drug Interactions Program ) BCG: Antibiotics may diminish the therapeutic effect of BCG. Risk X: Avoid combination Capreomycin: May enhance the neuromuscular-blocking effect of Polymyxin B. Risk C: Monitor therapy Colistimethate: Polymyxin B may enhance the neuromuscular-blocking effect of Colistimethate. Risk C: Monitor therapy Neuromuscular-Blocking Agents: Polymyxin B may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents. Risk D: Consider therapy modification Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. Management: Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Risk D: Consider therapy modification Pregnancy Risk Factor C ( show table ) Pregnancy Implications Animal reproduction studies have not been conducted with this combination. See individual agents. Pharmacokinetics (Adult data unless noted) Absorption: Insignificant from intact skin or mucous membrane Patient Information (For additional information see "Bacitracin and polymyxin B: Patient drug information" ) Do not use longer than 1 week unless directed by physician; ophthalmic ointment may cause blurred vision Use of UpToDate is subject to the Subscription and License Agreement . Topic 12977 Version 34.0 © 2013 UpToDate, Inc. All rights reserved. | Subscription and License Agreement | Release: 21.6- C21.56 Licensed to: AsanBook Dig. Med. Lib. | Support Tag: [0504-61.55.141.10-50DD9E1A11-S244013.14]