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©2013 UpToDate ® Print Email Follicular lymphoma: bcl-2 staining Left panel: Neoplastic cells within the lymph node follicle from a patient with follicular lymphoma show strong immunostaining (brown color) for bcl-2. The lymphocytes in the thin mantles and the interfollicular regions also show bcl-2 reactivity. Right panel: In comparison, the germinal centers in a reactive follicle are bcl-2 negative, with the positive cells being located in the mantle and interfollicular regions. From Warnke, RA, Weiss, LM, Chan, JK, Cleary, ML, Dorfman, RF. Tumors of the lymph nodes and spleen. Atlas of tumor pathology (electronic fascicle), Third series, fascicle 14, 1995, Washington, DC. Armed Forces Institute of Pathology.