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Adverse Reactions Dermatologic: Erythema, pruritus Local: Anesthesia, hypoesthesia, irritation, pain Ocular: Ocular irritation Rare but important or life-threatening: Dandruff, dermatitis, dryness, excoriation, exfoliation, paresthesia, rash, thermal burn Contraindications Hypersensitivity to benzyl alcohol or any component Precautions For external use only; if contact with eyes occurs, flush immediately with water; allergic or irritant dermatitis may occur Warnings Large amounts of benzyl alcohol (≥99 mg/kg/day) have been associated with a potentially fatal toxicity ("gasping syndrome") in neonates; the "gasping syndrome" consists of metabolic acidosis, respiratory distress, gasping respirations, CNS dysfunction (including convulsions, intracranial hemorrhage), hypotension, and cardiovascular collapse; avoid use in neonates Metabolism/Transport Effects None known. Drug Interactions (For additional information: Launch Lexi-Interact™ Drug Interactions Program ) There are no known significant interactions. Pregnancy Risk Factor B ( show table ) Pregnancy Implications Teratogenic effects were not observed in animal studies. There are no well-controlled human studies with topical benzyl alcohol in pregnancy. Use only if clearly needed. Mechanism of Action Inhibits respiration of lice by obstructing respiratory spiracles causing lice asphyxiation. No ovicidal activity. Pharmacokinetics (Adult data unless noted) Absorption: Quantifiable serum plasma concentrations reported following prolonged exposure (30 minutes) in patients 6 months to 11 years of age Patient Information (For additional information see "Benzyl alcohol: Patient drug information" ) Lotion should be used in conjunction with overall lice management program. Dry clean or wash all clothing, hats, bedding, and towels in hot water. Wash all personal care items (eg, combs, brushes, hair clips) in hot water. May use a fine-tooth or special nit comb to remove nits and dead lice. May shampoo hair right after treatment. Keep topical liquid away from fire or flame. Inform physician if swelling, rash, or fever develops or if application site irritation occurs. Use of UpToDate is subject to the Subscription and License Agreement . Topic 13083 Version 26.0

Lotion should be used in conjunction with overall lice management program. Dry clean or wash all clothing, hats, bedding, and towels in hot water. Wash all personal care items (eg, combs, brushes, hair clips) in hot water. May use a fine-tooth or special nit comb to remove nits and dead lice. May shampoo hair right after treatment. Keep topical liquid away from fire or flame. Inform physician if swelling, rash, or fever develops or if application site irritation occurs. Use of UpToDate is subject to the Subscription and License Agreement . Topic 13083 Version 26.0 © 2013 UpToDate, Inc. All rights reserved. | Subscription and License Agreement | Release: 21.6- C21.56 Licensed to: AsanBook Dig. Med. Lib. | Support Tag: [0505-201.211.0.116-03DA1CD083-S244013.14]