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©2013 UpToDate ® Print Email Beta-lactam oral desensitization protocol Beta-lactam concentration (mg/mL)* Dose number • Amount given Δ (mL) Dose given (mg) 0.5 1 0.1 0.05 2 0.2 0.10 3 0.4 0.20 4 0.8 0.40 5 1.6 0.80 6 3.2 1.60 7 6.4 3.20 5 8 1.2 6 9 2.4 12 10 4.8 24 50 11 1 50 12 2 100 13 4 200 14 8 400 Upon completion of the steps above, observe patient for 30 minutes and then give full therapeutic dose by route of choice. * Dilutions prepared from antibiotic syrup, 250 mg/5 mL. • Dose approximately doubled every 15 minutes. Δ Drug amount given in 30 mL water or flavored beverage. Adapted from: Sullivan TJ. Drug allergy. In: Allergy: Principles and Practice, 4th Edition, Middleton EJ, Reed CE, Eliss EF, et al (Eds), St. Louis: Mosby, 1993. Table used with the permission of Elsevier Inc. All rights reserved.