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REFERENCES Burns SP, Iles RA, Ryalls M, et al “Methylgenesis From Betaine in Cystathionine-Beta-Synthase Deficiency,” Biochem Soc Trans , 1993, 21:455S. [PubMed 7510653 ] Devlin AM, Hajipour L, Gholkar A, “Cerebral Edema Associated With Betaine Treatment in Classical Homocystinuria,” J Pediatr , 2001,144(4):545-8. [PubMed 15069409 ] Kishi T, Kawamura I, Harada Y, et al, “Effect of Betaine on S-Adenosylmethionine Levels in the Cerebrospinal Fluid in a Patient With Methylenetetrahydrofolate Reductase Deficiency and Peripheral Neuropathy,” J Inherit Metab Dis , 1994, 17:560-5. [PubMed 7837762 ] Lawson-Yuen A and Levy, HL, “The Use of Betaine in the Treatment of Elevated Homocysteine,” Mol Genet Metab , 2006, 88(3):201-7. [PubMed 16545978 ] Matthews A, Johnson TN, Rostami-Hodjegan A, et al, “An Indirect Response Model of Homocysteine Suppression by Betaine: Optimising the Dosage Regimen of Betaine in Homocystinuria,” Br J Clin Pharmacol , 2002, 54(2):140-6. [PubMed 12207633 ] Smolin LA, Benevenga NJ, and Berlow S, “The Use of Betaine for the Treatment of Homocystinuria,” J Pediatr , 1981, 99:467-72. [PubMed 7264811 ] Topic 8598 Version 32.0 © 2013 UpToDate, Inc. All rights reserved. | Subscription and License Agreement | Release: 21.4 - C21.36 Licensed to: Southeast Alabama Med Ctr | Support Tag: [1004-122.72.76.133-1FB45B5B38-S244013.14]