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©2013 UpToDate ® Print Email Bethesda classification of cervical cytology Specimen type Conventional smear, liquid-based, or other technique Specimen adequacy Satisfactory for evaluation (description includes quality indicators, including endocervical/transformation zone component and obscuring blood or inflammation) Unsatisfactory due to... (specify reason) General categorization (optional) Negative for intraepithelial lesion or malignancy Epithelial cell abnormality (specify squamous or glandular) Other: see interpretation/result (eg, endometrial cells in woman ≥age 40) Automated review If examined by a device, specify device and result Ancillary testing Describe method and result (eg, molecular testing) Interpretation/result Negative for intraepithelial lesion or malignancy (when there is absence of neoplasia this should be stated specifically, regardless of other findings) In addition describe, if present: Infection (Trichomonas vaginalis, Candida spp, shift in flora consistent with bacterial vaginosis, Actinomyces spp, cellular changes) Other nonneoplastic findings, such as, but not limited to: Reactive cellular changes associated with inflammation/cellular repair, radiation, or an intrauterine contraceptive device Glandular cells post hysterectomy Atrophy Other Endometrial cells (in a woman ≥age 40) and specify whether negative for squamous intraepithelial lesion Epithelial cell abnormalities Squamous cell Atypical squamous cells (ASC) of undetermined significance (ASC-US) cannot exclude HSIL (ASC-H) Low grade squamous intraepithelial lesion (LSIL) cellular changes consistent with HPV, mild dysplasia, CIN 1 High grade squamous intraepithelial lesion (HSIL) moderate/severe dysplasia, CIN 2, CIN 3, CIS indicate if there are features suspicious for invasion (if invasion suspected) Squamous cell carcinoma Glandular cell Atypical Endocervical cells Endometrial cells Not otherwise specified Atypical, favor neoplastic Endocervical cells Not otherwise specified Endocervical adenocarcinoma in situ (AIS) Adenocarcinoma Other malignant neoplasms (specify) Educational notes and suggestions Suggestions should be concise and consistent with clinical follow-up guidelines published by professional organizations Solomon D, Davey D, Kurman R, et al. The 2001 Bethesda system: terminology for reporting results of cervical cytology. JAMA 2002; 287:2114.