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©2013 UpToDate ® Print Email Binet Staging System For Chronic Lymphocytic Leukemia Stage Description A Two or less lymphoid bearing areas enlarged* B Three or more lymphoid bearing areas enlarged* C Presence of anemia (Hgb <10.0 g/dL) or thrombocytopenia (platelet count <100,000/microL) * Five lymphoid bearing areas are possible: cervical, axillary, inguino-femoral, spleen, and liver. Revised from Binet, JL, Auquier, A, Dighiero, G, et al. Cancer 1981; 48:198.
©2013 UpToDate ® Print Email Binet Staging System For Chronic Lymphocytic Leukemia Stage Description A Two or less lymphoid bearing areas enlarged* B Three or more lymphoid bearing areas enlarged* C Presence of anemia (Hgb <10.0 g/dL) or thrombocytopenia (platelet count <100,000/microL) * Five lymphoid bearing areas are possible: cervical, axillary, inguino-femoral, spleen, and liver. Revised from Binet, JL, Auquier, A, Dighiero, G, et al. Cancer 1981; 48:198. Modified Rai clinical staging system for chronic lymphocytic leukemia Risk Stage Description Low 0 Lymphocytosis in blood or bone marrow Intermediate I Lymphocytosis + enlarged lymph nodes II Lymphocytosis + enlarged liver or spleen with orwithout lymphadenopathy High III Lymphocytosis + anemia (Hgb <11 g/dL)with or without enlarged liver, spleen, or lymph lnodes IV Lymphocytosis + thrombocytopenia (platelet count<100,000/µL) with or without anemia or enlarged liver,spleen, or lymph nodes