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©2013 UpToDate ® Print Email Bone penetration for selected antibiotics Antibiotic Range of mean bone to serum concentration ratios Levofloxacin 0.36-1.0 Ciprofloxacin 0.27-1.2 Moxifloxacin 0.33-1.05 Vancomycin 0.05-0.67 Linezolid 0.2-0.51 Daptomycin 1.17* Clindamycin 0.21-0.45 Cefazolin 0.179 Ceftriaxone 0.07-0.17 Cefuroxime 0.04-0.55 Rifampin (rifampicin) 0.08-0.57 Numerous factors account for a wide range of bone to serum concentration ratios reported, including variation in timing/technique of sampling, analytical method, and condition of bone. * Data are limited to a case series of nine diabetic patients with foot infection and osteomyelitis. Data from: Landersdorfer CB, Bulitta JB, Kinzig M, et al. Penetration of antibacterials into bone: pharmacokinetic, pharmacodynamic and bioanalytical considerations. Clin Pharmacokinet 2009; 48:89. von Baum H, Böttcher S, Abel R, et al. Tissue and serum concentrations of levofloxacin in orthopaedic patients. Int J Antimicrob Agents 2001; 18:335. Garazzino S, Aprato, A, Baietto, L, et al. Glycopeptide bone penetration in patients with septic pseudoarthrosis of the tibia. Clin Pharmacokinet 2008; 47:793. Traunmuller F, Schintler MV, Metzler J, et al. Soft tissue and bone penetration abilities of daptomycin in diabetic patients with bacterial foot infections. J Antimicrob Chemother 2010; 65:1252.