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©2013 UpToDate ® Print Email Mean change (±SE) in six-minute walking distance from baseline to week 16 in the placebo and bosentan groups P<0.01 for the comparison between the 125-mg dose of bosentan and placebo, and P<0.001 for the comparison between the 250-mg dose and placebo by the Mann-Whitney U test. There was no significant difference between the two bosentan groups (P=0.18 by the Mann-Whitney U test). Data from: Rubin LJ, Badesch, DB, Barst, RJ, et al. Bosentan therapy for pulmonary arterial hypertension. N Engl J Med 2002; 346:896.