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©2013 UpToDate ® Print Email Brain MRI, 1-year-old girl with Canavan disease T2-weighted (A, B) and T1-weighted (C, D) MRI of the brain showing severe and diffuse T2 hyperintense and T1 hypointense signal changes in the white matter suggesting Canavan disease. Significant involvement of U fibers is present. Multiple round or oval cystic changes within the white matter give a honeycomb appearance. The radial arrangement of these cystic spaces suggests dilatation of Virchow-Robin spaces due to spongiform degeneration of the white matter. Reproduced with permission from: Pradhan S, Goyal G. Teaching NeuroImages: honeycomb appearance of the brain in a patient with Canavan disease. Neurology 2011; 76:e68. Copyright © 2011 Lippincott Williams & Wilkins.