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Walk the Even Hospital Database by book and chapter — the raw source passages that ground Ask, DDx, and the rest.
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©2013 UpToDate ® Print Email Brain MRI of a 16 year old girl with vanishing white matter disease MR images of Patient 3. Shown are the transverse T2-weighted (A, B), proton density (C), and coronal fluid-attenuated inversion recovery (FLAIR) (D) images. The abnormal cerebral hemispheric white matter has a homogeneously high signal on T2-weighted images, but partly high and partly low signals on proton density and FLAIR images. The signal intensity is lowest in the white matter closest to the lateral ventricles (C, D). Note the radiating stripelike pattern in the low-signal intensity areas (C, D). Within the posterior limb of the internal capsule, a double line of signal abnormality is seen (B; arrows). Within the brainstem, the central tegmental tracts (A; small arrows) and transverse pontine fibers (A; large arrows) are involved. Reproduced with permission from: Van der Knaap MS, Kamphorst W, Barth PG. Phenotypic variation in leukoencephalopathy with vanishing white matter. Neurology 1998; 51:540. Copyright © 1998 Lippincott Williams & Wilkins.