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©2013 UpToDate ® Print Email Conventional cerebral MRI imaging in adult-onset vanishing white matter disease Sagittal T2-weighted (A) and axial fluid-attenuated inversion recovery (FLAIR) (B) are shown. Virtually, all hemispheric white matter appeared homogeneously hyperintense on T2-weighted and hypointense on T1-weighted (not shown) with atrophy of the corpus callosum. On FLAIR, large part of the white matter has a signal identical to CSF, surrounded by a rim of hyperintensity demonstrating the cavitated breakdown of the white matter. Reproduced with permission from: Denier C, Orgibet A, Roffi F. Adult-Onset vanishing white matter leukoencephalopathy presenting as psychosis. Neurology 2007; 68:1538. Copyright © 2007 Lippincott Williams & Wilkins.