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©2013 UpToDate ® Print Email Risk of breast cancer Percent of population Percent of all breast cancer cases Average risk of breast cancer to age 70 Positive family history breast cancer* ~10 15 to 20 10 to 13 percent • Positive BRCA1 or 2 mutation ~0.1 5 to 6 50 to 85 percent Δ General population without positive family history or BRCA mutation ~90 80 to 85 7 ◊ percent * Breast cancer in a first-degree relative. • Data from: Colditz G, et al. JAMA 1993; 270:338. Δ This range represents the range of lifetime risk quoted by genetic specialists. ◊ Data from: the American Cancer Society, Cancer Statistics, 2010. (CA Cancer J Clin 2010; 60:277).