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Note: All dosing is presented in terms of brompheniramine maleate and phenylephrine hydrochloride: Brompheniramine 1 mg and phenylephrine 2.5 mg per 5 mL: 20 mL every 4-6 hours (maximum: 120 mL/24 hours) Brompheniramine 1.2 mg and phenylephrine 2 mg per 1 mL : 3 mL every 4-6 hours (maximum: 18 mL/24 hours) Brompheniramine 4 mg and phenylephrine 10 mg per 5 mL: 5 mL every 4-6 hours; (maximum: 30 mL/24 hours) Brompheniramine 6 mg and phenylephrine 10 mg per 5 mL: 5 mL every 6 hours (maximum: 20 mL/24 hours) Dosing: Pediatric

Note: All dosing is presented in terms of brompheniramine maleate and phenylephrine hydrochloride: Children 2-5 years: Brompheniramine 1 mg and phenylephrine 2.5 mg per 5 mL: 5 mL every 4 hours (maximum: 30 mL/24 hours) Children 6-11 years: Brompheniramine 1 mg and phenylephrine 2.5 mg per 5 mL: 10 mL every 4-6 hours (maximum: 60 mL/24 hours) Brompheniramine 1.2 mg and phenylephrine 2 mg per 1 mL : 1.5 mL every 4-6 hours (maximum: 9 mL/24 hours) Brompheniramine 4 mg and phenylephrine 10 mg per 5 mL: 2.5 mL every 4-6 hours (maximum: 15 mL/24 hours) Children ≥12 years: Refer to adult dosing. Dosing: Geriatric Refer to adult dosing. Dosage Forms: U.S. Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Elixir, oral: Dimaphen™ Children's Cold & Allergy: Brompheniramine maleate 1 mg and phenylephrine hydrochloride 2.5 mg per 5 mL (118 mL, 237 mL) [ethanol free, gluten free; contains propylene glycol, sodium 2 mg/5 mL, sodium benzoate; grape flavor] Liquid, oral: BroveX™ PEB: Brompheniramine maleate 4 mg and phenylephrine hydrochloride 10 mg per 5 mL (473 mL) [dye free, ethanol free, gluten free, sugar free; contains propylene glycol; bubblegum flavor] Dimetapp® Children’s Cold & Allergy: Brompheniramine maleate 1 mg and phenylephrine hydrochloride 2.5 mg per 5 mL (118 mL, 237 mL) [ethanol free; contains sodium 3 mg/5 mL, propylene glycol, sodium benzoate; grape flavor] LoHist PEB: Brompheniramine maleate 4 mg and phenylephrine hydrochloride 10 mg per 5 mL (118 mL, 473 mL) [dye free, ethanol free, sugar free; contains propylene glycol, sodium benzoate; bubble gum flavor] Rynex PE: Brompheniramine maleate 1 mg and phenylephrine hydrochloride 2.5 mg per 5 mL (473 mL) [ethanol free, gluten free, sugar free; contains propylene glycol; bubblegum flavor] Suspension, oral: Entre-B: Brompheniramine maleate 6 mg and phenylephrine hydrochloride 10 mg per 5 mL (118 mL) [contains benzoic acid, propylene glycol; bubble gum flavor] Vazobid-PD™: Brompheniramine maleate 1.2 mg and phenylephrine hydrochloride 2 mg per 1 mL (118 mL) [contains aspartame, sodium benzoate; bubblegum flavor] Generic Equivalent Available: U.S. Yes Administration Shake suspension well before use.

Entre-B: Brompheniramine maleate 6 mg and phenylephrine hydrochloride 10 mg per 5 mL (118 mL) [contains benzoic acid, propylene glycol; bubble gum flavor] Vazobid-PD™: Brompheniramine maleate 1.2 mg and phenylephrine hydrochloride 2 mg per 1 mL (118 mL) [contains aspartame, sodium benzoate; bubblegum flavor] Generic Equivalent Available: U.S. Yes Administration Shake suspension well before use. Use Temporary relief of upper respiratory conditions such as nasal congestion, runny nose, itchy/watery eyes, and sneezing due to the common cold, hay fever, or upper respiratory allergies Adverse Reactions Significant See individual agents. Contraindications Hypersensitivity to brompheniramine, phenylephrine, or any component of the formulation; use with or within 14 days of MAO inhibitor therapy; do not use to sedate a child; newborns; breast-feeding Additional contraindications per some manufacturers: Severe CAD, severe hypertension; narrow angle glaucoma; urinary retention; peptic ulcer; acute asthma attack Warnings/Precautions

Disease-related concerns: • Cardiovascular disease: Use with caution in patients with cardiovascular disease (including hypertension). • Diabetes: Use with caution in patients with diabetes mellitus. • Increased intraocular pressure/glaucoma: Use with caution in patients with increased intraocular pressure or glaucoma. • Prostatic hyperplasia/urinary obstruction: Use with caution in patients with prostatic hyperplasia and/or GU obstruction. • Pyloroduodenal obstruction: Use with caution in patients with pyloroduodenal obstruction (including stenotic peptic ulcer). • Respiratory disease: Use with caution in patients with asthma or other chronic breathing disorders. • Thyroid dysfunction: Use with caution in patients with thyroid dysfunction.

Special populations: • Elderly: Use with caution in the elderly; may be more sensitive to adverse effects. • Pediatrics: Antihistamines may cause excitation in young children. Do not exceed pediatric dosing recommendations. If no recommendations exist on OTC labeling for patient’s age, the product should not be administered without the guidance of a physician.

Other warnings/precautions: • Self-medication (OTC use): When used for self medication (OTC), notify healthcare provider if symptoms do not improve within 7 days or are accompanied by fever. Discontinue and contact healthcare provider if nervousness, dizziness, or sleeplessness occur. Ethanol/Nutrition/Herb Interactions Ethanol: May increase CNS depression. Management: Monitor for increased effects with coadministration; caution patients about effect. Dietary Considerations Some products contain sodium. Pricing: U.S. (Medi-Span®)

Suspension (Vazobid-PD Oral) 6-10 mg/5 mL (118 mL): $40.77 Pharmacodynamics/Kinetics See individual agents. Use of UpToDate is subject to the Subscription and License Agreement . Topic 9070 Version 31.0 © 2013 UpToDate, Inc. All rights reserved. | Subscription and License Agreement | Release: 21.6- C21.56 Licensed to: AsanBook Dig. Med. Lib. | Support Tag: [0503-200.167.4.114-3ADB073D65-S244013.14]