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contentuptodate· Content· item f1_42_1697

©2013 UpToDate ® Print Email Severe bullous disease in alpha-1 antitrypsin deficiency Large bilateral subpleural bullae lead to retraction of the underlying normal lung parenchyma. The bullae have an increased compliance and allow normal lung to retract according to its intrinsic elastic recoil. The bullae are not under tension; their effect is similar to that of a pneumothorax ("intrapulmonary pneumothorax"). Courtesy of Paul Stark, MD.