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©2013 UpToDate ® Print Email Bullous pemphigoid This hematoxylin and eosin stain of a skin tissue biopsy specimen from an early lesion of bullous pemphigoid demonstrates epidermal spongiosis, eosinophils within the epidermis, and a mixed perivascular cellular infiltrate in the upper dermis. Reproduced with permission from: Leiferman KM, Peters MS. Eosinophils in cutaneous diseases. In: Fitzpatrick's Dermatology in General Medicine, 8th ed, Goldsmith L, Katz S, Gilchrest B, et al (Eds), McGraw-Hill, New York 2012. Copyright © 2012 McGraw-Hill Companies, Inc.