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contentuptodate· Content· item f26_44_27338

©2013 UpToDate ® Print Email Bullous pemphigoid This hematoxylin and eosin stain of a skin tissue biopsy specimen from the edge of an established lesion of bullous pemphigoid demonstrates a subepidermal blister with an edematous papillary dermis as its base. The roof of the blister consists of the intact epidermis, including the stratum basalis. Eosinophil-rich inflammatory cells, fibrin, and tissue fluid fill the blister. Reproduced with permission from: Rubin, E, Farber, JL. Pathology, 3rd ed, Lippincott Williams & Wilkins, Philadelphia 1999. Copyright ©1999 Lippincott Williams & Wilkins. Direct immunofluorescence microscopy of bullous pemphigoid Direct immunofluorescence microscopy reveals linear IgG and C3 basement membrane zone staining (IgG shown here). 200 X. Courtesy of Kristin M Leiferman, MD, Immunodermatology Laboratory, Department of Dermatology, University of Utah, Salt Lake City, Utah.

contentuptodate· Content· item f43_15_44279

©2013 UpToDate ® Print Email Bullous pemphigoid This hematoxylin and eosin stain of a skin tissue biopsy specimen from the edge of an established lesion of bullous pemphigoid demonstrates a subepidermal blister with an edematous papillary dermis as its base. The roof of the blister consists of the intact epidermis, including the stratum basalis. Eosinophil-rich inflammatory cells, fibrin, and tissue fluid fill the blister. Reproduced with permission from: Rubin, E, Farber, JL. Pathology, 3rd ed, Lippincott Williams & Wilkins, Philadelphia 1999. Copyright ©1999 Lippincott Williams & Wilkins.