Browse the corpus
Walk the Even Hospital Database by book and chapter — the raw source passages that ground Ask, DDx, and the rest.
2 passages
©2013 UpToDate ® Print Email C-ANCA pattern on indirect immunofluorescence Demonstration of cytoplasmic antineutrophil cytoplasmic antibodies (C-ANCA) by indirect immunofluorescence with normal neutrophils. There is heavy staining in the cytoplasm while the multilobulated nuclei (clear zones) are nonreactive. These antibodies are usually directed against proteinase 3, and most patients have granulomatosis with polyangiitis (Wegener’s). Courtesy of Helmut Rennke, MD. P-ANCA pattern on indirect immunofluorescence Demonstration of perinuclear antineutrophil cytoplasmic antibodies (P-ANCA) by indirect immunofluorescence with normal neutrophils. Staining is limited to the perinuclear region, and the cytoplasm is nonreactive. Among patients with vasculitis, the antibodies are usually directed against myeloperoxidase. However, a P-ANCA pattern can also be seen with autoantibodies against a number of other antigens including lactoferrin and elastase. Non-MPO P-ANCA can be seen in a variety of nonvasculitic disorders. Courtesy of Helmut Rennke, MD.
©2013 UpToDate ® Print Email C-ANCA pattern on indirect immunofluorescence Demonstration of cytoplasmic antineutrophil cytoplasmic antibodies (C-ANCA) by indirect immunofluorescence with normal neutrophils. There is heavy staining in the cytoplasm while the multilobulated nuclei (clear zones) are nonreactive. These antibodies are usually directed against proteinase 3, and most patients have granulomatosis with polyangiitis (Wegener’s). Courtesy of Helmut Rennke, MD.