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©2013 UpToDate ® Print Email Structure of the complement component 1 (C1) complex A model of the C1 complex showing the intertwining of C1s-C1r-C1r-C1s in the C1q subcomponent. This structure permits the catalytic domains of C1s to contact the catalytic domains of C1r. The Fc portion of IgG and IgM engages the globular head of C1. Adapted from: Liszewski, MK, Atkinson, JP. The complement system. In: Immunology Scope Monograph, Schwart BD (Ed), Upjohn, Kalamazoo 1992.) Structure of C1.