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©2013 UpToDate ® Print Email CDC algorithm for screening for GBS in preterm labor before 37 weeks CDC: Centers for Disease Control and Prevention; GBS: Group B streptococcus. * If patient has undergone vaginal-rectal GBS culture within the preceding 5 weeks, the results of that culture should guide management. GBS-colonized women should receive intrapartum antibiotic prophylaxis. No antibiotics are indicated for GBS prophylaxis if a vaginal-rectal screen within 5 weeks was negative. • Patient should be regularly assessed for progression to true labor; if the patient is considered not to be in true labor, discontinue GBS prophylaxis. Δ If GBS culture results become available prior to delivery and are negative, then discontinue GBS prophylaxis. ◊ Unless subsequent GBS culture prior to delivery is positive. § A negative GBS screen is considered valid for 5 weeks. If a patient with a history of PTL is re-admitted with signs and symptoms of preterm labor and had a negative GBS screen >5 weeks prior, she should be rescreened and managed according to this algorithm at that time. Reproduced from: Centers for Disease Control and Prevention. Prevention of Perinatal Group B Streptococcal Disease. Revised Guidelines from CDC, 2010. MMWR 2010; 59:No. RR-10.