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©2013 UpToDate ® Print Email Fat-soluble vitamins preparations for individuals with cystic fibrosis* Age SourceCF® (drops, chewables, softgels) AquADEK® (chewables) AquADEKs® (drops, softgels) Vitamax® (drops, chewables) Poly-Vi-Sol® (drops) Centrum® (chewable, tablet) Total Vitamin A (International Units, IU) (Retinol and Beta Carotene) 0-12 months 4627 IU/1 mL 75 percent as beta-carotene - 5751 IU/1 mL 87 percent as beta-carotene 3170 IU/1 mL as 100 percent retinol palmitate 1500 IU/1 mL 1-3 yrs 9254 IU/2 mL 75 percent as beta-carotene - 11,502 IU/2 mL 87 percent as beta-carotene 6340 IU/2 mL as 100 percent retinol palmitate 3000 IU/2 mL 4-8 yrs 16,000 IU/1 chewable 88 percent as beta-carotene For ages 4-10 years: 18,167 IU/2 chewables 92 percent as beta-carotene For ages 4-10 years: 18,167 IU/1 softgel 92 percent as beta-carotene 5000 IU/1 chewable 50 percent as beta-carotene 3500 IU/1 chewable 29 percent as beta-carotene 9-18 yrs 32,000 IU/2 softgels 88 percent as beta-carotene For ages 10 and up: 36,334 IU/4 chewables 92 percent as beta-carotene For ages 10 and up: 36,334 IU/2 softgels 92 percent as beta-carotene 10,000 IU/2 chewables 50 percent as beta-carotene 7000 IU/2 tablets 29 percent as beta-carotene >18 yrs 32,000 IU/2 softgels 88 percent as beta-carotene 36,334 IU/4 chewables 92 percent as beta-carotene 36,334 IU/2 softgels 92 percent as beta-carotene 10,000 IU/2 chewables 50 percent as beta-carotene 7000 IU/2 tablets 29 percent as beta-carotene Vitamin E (International Units, IU) 0-12 months 50 IU/1 mL - 50 IU/1 mL • 50 IU/1 mL 5 IU/1 mL 1-3 yrs 100 IU/2 mL - 100 IU/2 mL • 100 IU/2 mL 10 IU/2 mL 4-8 yrs 200 IU/1 chewable For ages 4-10 years: 100 IU/2 chewables For ages 4-10 years: 150 IU/1 softgel 200 IU/1 chewable 30 IU/1 chewable 9-18 yrs 400 IU/2 softgels For ages 10 and up: 200 IU/4 chewables For ages 10 and up: 300 IU/2 softgels 400 IU/2 chewables 60 IU/2 tablets >18 yrs 400 IU/2 softgels 200 IU/4 chewables 300 IU/2 softgels 400 IU/2 chewables 60 IU/2 tablets Vitamin D (International Units, IU) 0-12 months 500 IU/1 mL - 400 IU/1 mL 400 IU/1 mL 400 IU/1 mL 1-3 yrs 1000 IU/2 mL - 800 IU/2 mL 800 IU/2 mL 800 IU/2 mL 4-8 yrs 1000 IU/1 chewable For ages 4-10 years: 800 IU/2 chewables For ages 4-10 years: 800 IU/1 softgel 400 IU/1 chewable 400 IU/1 chewable 9-18 yrs 2000 IU/2 softgels For ages 10 and up: 1600 IU/4 chewables For ages 10 and up: 1600 IU/2 softgels 800 IU/2 chewables 800 IU/2 tablets >18 yrs 2000 IU/2 softgels 1600 IU/4 chewables 1600 IU/2 softgels 800 IU/2 chewables 800 IU/2 tablets Vitamin K (mcg) 0-12 months 400 mcg/1 mL - 400 mcg/1 mL 300 mcg/1 mL 0 mcg 1-3 yrs 800 mcg/2 mL - 800 mcg/2 mL 600 mcg/2 mL 0 mcg 4-8 yrs 800 mcg/1 chewable For ages 4-10 years: 700 mcg/2 chewables

1600 IU/4 chewables For ages 10 and up: 1600 IU/2 softgels 800 IU/2 chewables 800 IU/2 tablets >18 yrs 2000 IU/2 softgels 1600 IU/4 chewables 1600 IU/2 softgels 800 IU/2 chewables 800 IU/2 tablets Vitamin K (mcg) 0-12 months 400 mcg/1 mL - 400 mcg/1 mL 300 mcg/1 mL 0 mcg 1-3 yrs 800 mcg/2 mL - 800 mcg/2 mL 600 mcg/2 mL 0 mcg 4-8 yrs 800 mcg/1 chewable For ages 4-10 years: 700 mcg/2 chewables For ages 4-10 years: 700 mcg/1 softgel 200 mcg/1 chewable 10 mcg/1 chewable 9-18 yrs 1600 mcg/2 softgels 1400 mcg/4 chewables For ages 10 and up: 1400 mcg/2 softgels 400 mcg/2 chewables 50 mcg/2 tablets >18 yrs 1600 mcg/2 softgels 1400 mcg/4 chewables 1400 mcg/2 softgels 400 mcg/2 chewables 50 mcg/2 tablets AquADEKs® is a registered trademark of Yasoo Health Inc, Vitamax® is a registered trademark of Shear/Kershman Labs. Inc, Poly-Vi-Sol® is a registered trademark of Mead Johnson and Company, Centrum® is a registered trademark of Wyeth Consumer Care. * The content of this table was confirmed with each company as of December 2008. • Also contains mixed tocopherols. Reproduced with permission from: Eurand Pharmaceuticals, Inc. All rights reserved. Available at: file://www.sourcecf.com/pdf/VitaminComparisonTablenew.pdf.

1600 IU/4 chewables For ages 10 and up: 1600 IU/2 softgels 800 IU/2 chewables 800 IU/2 tablets >18 yrs 2000 IU/2 softgels 1600 IU/4 chewables 1600 IU/2 softgels 800 IU/2 chewables 800 IU/2 tablets Vitamin K (mcg) 0-12 months 400 mcg/1 mL - 400 mcg/1 mL 300 mcg/1 mL 0 mcg 1-3 yrs 800 mcg/2 mL - 800 mcg/2 mL 600 mcg/2 mL 0 mcg 4-8 yrs 800 mcg/1 chewable For ages 4-10 years: 700 mcg/2 chewables For ages 4-10 years: 700 mcg/1 softgel 200 mcg/1 chewable 10 mcg/1 chewable 9-18 yrs 1600 mcg/2 softgels 1400 mcg/4 chewables For ages 10 and up: 1400 mcg/2 softgels 400 mcg/2 chewables 50 mcg/2 tablets >18 yrs 1600 mcg/2 softgels 1400 mcg/4 chewables 1400 mcg/2 softgels 400 mcg/2 chewables 50 mcg/2 tablets AquADEKs® is a registered trademark of Yasoo Health Inc, Vitamax® is a registered trademark of Shear/Kershman Labs. Inc, Poly-Vi-Sol® is a registered trademark of Mead Johnson and Company, Centrum® is a registered trademark of Wyeth Consumer Care. * The content of this table was confirmed with each company as of December 2008. • Also contains mixed tocopherols. Reproduced with permission from: Eurand Pharmaceuticals, Inc. All rights reserved. Available at: file://www.sourcecf.com/pdf/VitaminComparisonTablenew.pdf. Supplements of water-soluble vitamins and zinc for individuals with cystic fibrosis* Age SourceCF® (drops, chewables, softgels) ADEKs® (chewables) AQUADEKs® (drops, softgels) Vitamax® (drops, chewables) Poly-Vi-Sol® (drops) Centrum® (chewable, tablet) Thiamin B1 (mg) Infants 0.5 mg/1 mL - 0.6 mg/1 mL 0.5 mg/1 mL 0.5 mg/1 mL 1-3 years 1 mg/2 mL - 1.2 mg/2 mL 1 mg/2 mL 1 mg/2 mL Children 4-8 years 1.5 mg/1 chewable 1.2 mg/1 chewable For 4-10 yrs: 1.5 mg/1 softgel 1.5 mg/1 chewable 1.5 mg/1 chewable 9 yrs to adults 3 mg/2 softgels 2.4 mg/2 chewables For ages 10+: 3 mg/2 softgels 3 mg/2 chewables 3 mg/2 tablets Riboflavin B2 (mg) Infants 0.6 mg/1 mL - 0.6 mg/1 mL 0.6 mg/1 mL 0.6 mg/1 mL 1-3 years 1.2 mg/2 mL - 1.2 mg/2 mL 1.2 mg/2 mL 1.2 mg/2 mL Children 4-8 years 1.7 mg/1 chewable 1.3 mg/1 chewable For 4-10 yrs: 1.7 mg/1 softgel 1.7 mg/1 chewable 1.7 mg/1 chewable 9 yrs to adults 3.4 mg/2 softgels 2.6 mg/2 chewables For ages 10+: 3.4 mg/2 softgels 3.4 mg/2 chewables 3.4 mg/2 tablets Niacin (mg) Infants 6 mg/1 mL - 6 mg/1 mL 6 mg/1 mL 8 mg/1 mL 1-3 years 12 mg/2 mL - 12 mg/2 mL 12 mg/2 mL 16 mg/2 mL Children 4-8 years 10 mg/1 chewable 10 mg/1 chewable For 4-10 yrs: 20 mg/1 softgel 20 mg/1 chewable 20 mg/1 chewable 9 yrs to adults 40 mg/2 softgels 20 mg/2 chewables For ages 10+: 40 mg/2 softgels 40 mg/ 2 chewables 40 mg/2 tablets Pyridoxine B6 (mg) Infants 0.6 mg/1 mL - 0.6 mg/1 mL 0.6 mg/1 mL 0.4 mg/1 mL 1-3 years 1.2 mg/2 mL - 1.2 mg/2 mL 1.2 mg/2 mL 0.8 mg/2 mL Children 4-8 years 1.9 mg/1 chewable 1.5 mg/1 chewable

10 mg/1 chewable For 4-10 yrs: 20 mg/1 softgel 20 mg/1 chewable 20 mg/1 chewable 9 yrs to adults 40 mg/2 softgels 20 mg/2 chewables For ages 10+: 40 mg/2 softgels 40 mg/ 2 chewables 40 mg/2 tablets Pyridoxine B6 (mg) Infants 0.6 mg/1 mL - 0.6 mg/1 mL 0.6 mg/1 mL 0.4 mg/1 mL 1-3 years 1.2 mg/2 mL - 1.2 mg/2 mL 1.2 mg/2 mL 0.8 mg/2 mL Children 4-8 years 1.9 mg/1 chewable 1.5 mg/1 chewable For 4-10 yrs: 1.9 mg/1 softgel 2 mg/1 chewable 2 mg/1 chewable 9 yrs to adults 3.8 mg/2 softgels 3 mg/2 chewables For ages 10+: 3.8 mg/2 softgels 4 mg/2 chewables 4 mg/2 tablets B12 (mcg) Infants 4 mcg/1 mL - 0 mcg 4 mcg/1 mL 2 mcg/1 mL 1-3 years 8 mcg/2 mL - 0 mcg 8 mcg/2 mL 4 mcg/2 mL Children 4-8 years 6 mcg/1 chewable 12 mcg/1 chewable For 4-10 yrs: 12 mcg/1 softgel 6 mcg/1 chewable 6 mcg/1 chewable 9 yrs to adults 12 mcg/2 softgels 24 mcg/2 chewables For ages 10+: 24 mcg/2 softgels 12 mcg/2 chewables 12 mcg/2 tablets Biotin (mcg) Infants 15 mcg/1 mL - 15 mcg/1 mL 15 mcg/1 mL 0 mcg 1-3 years 30 mcg/2 mL - 30 mcg/2 mL 30 mcg/2 mL 0 mcg Children 4-8 years 100 mcg/1 chewable 50 mcg/1 chewable For 4-10 yrs: 100 mcg/1 softgel 300 mcg/1 chewable 45 mcg/1 chewable 9 yrs to adults 200 mcg/2 softgels 100 mcg/2 chewables For ages 10+: 200 mcg/2 softgels 600 mcg/2 chewables 60 mcg/2 tablets Folic Acid (mcg) Infants 0 mcg - 0 mcg 0 mcg 0 mcg 1-3 years 0 mcg - 0 mcg 0 mcg 0 mcg Children 4-8 years 200 mcg/1 chewable 200 mcg/1 chewable For 4-10 yrs: 200 mcg/1 softgel 200 mcg/1 chewable 400 mcg/1 chewable 9 yrs to adults 400 mcg/2 softgels 400 mcg/2 chewables For ages 10+: 400 mcg/2 softgels 400 mcg/2 chewables 800 mcg/2 tablets Ascorbic Acid C (mg) Infants 45 mg/1 mL - 45 mg/1 mL 45 mg/1 mL 35 mg/1 mL 1-3 years 90 mg/2 mL - 90 mg/2 mL 90 mg/2 mL 70 mg/2 mL Children 4-8 years 100 mg/1 chewable 60 mg/1 chewable For 4-10 yrs: 75 mg/1 softgel 60 mg/1 chewable 60 mg/1 chewable 9 yrs to adults 200 mg/2 softgels 120 mg/2 chewables For ages 10+: 150 mg/2 softgels 120 mg/2 chewables 120 mg/2 tablets Pantothenic Acid (mg) Infants 3 mg/1 mL - 3 mg/1 mL 3 mg/1 mL 0 mg 1-3 years 6 mg/2 mL - 6 mg/2 mL 6 mg/2 mL 0 mg Children 4-8 years 12 mg/1 chewable 10 mg/1 chewable For 4-10 yrs: 12 mg/1 softgel 10 mg/1 chewable 10 mg/1 chewable 9 yrs to adults 24 mg/2 softgels 20 mg/2 chewables For ages 10+: 24 mg/2 softgels 20 mg/2 chewables 20 mg/2 tablets Zinc (mg) Infants 5 mg/1 mL - 5 mg/1 mL 7.5 mg/1 mL 0 mg 1-3 years 10 mg/2 mL - 10 mg/2 mL 15 mg/2 mL 0 mg Children 4-8 years 15 mg/1 chewable 7.5 mg/1 chewable For 4-10 yrs: 10 mg/1 softgel 7.5 mg/1 chewable 15 mg/1 chewable 9 yrs to adults 30 mg/2 softgels 15 mg/2 chewables For ages 10+: 20 mg/2 softgels 15 mg/2 chewables 22 mg/2 tablets * The content of this table was confirmed with each company as of December 2008.

1-3 years 10 mg/2 mL - 10 mg/2 mL 15 mg/2 mL 0 mg Children 4-8 years 15 mg/1 chewable 7.5 mg/1 chewable For 4-10 yrs: 10 mg/1 softgel 7.5 mg/1 chewable 15 mg/1 chewable 9 yrs to adults 30 mg/2 softgels 15 mg/2 chewables For ages 10+: 20 mg/2 softgels 15 mg/2 chewables 22 mg/2 tablets * The content of this table was confirmed with each company as of December 2008. Reproduced with permission from: Eurand Pharmaceuticals, Inc. All rights reserved. Available at: file://www.sourcecf.com/pdf/VitaminComparisonTablenew.pdf.