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©2013 UpToDate ® Print Email Lipid lowering improves coronary outcome in patients with CHD Trial Treatment regimen Duration, years CHD event reduction,percent NHLBI, type II Diet plus resin 5 33 STARS Diet plus resin 3 89* CLAS Diet plus resin plusniacin 2 25 CLAS II Diet plus resin plus niacin 4 43 FATS Diet plus resin plus niacin 2.5 80* FATS Dietplus resin plus lovastatin 2.5 70 MARS Diet plus lovastatin 2 28 CCAIT Diet plus lovastatin 2 22 SCRIP Diet plus drugs plus lovastatin (36%) 4 50* PLAC I Diet plus pravastatin 3 62* PLAC II Diet pluspravastatin 3 60 REGRESS Diet plus pravastatin 2 42* MAAS Diet plus pravastatin 4 22 4S Diet plussimvastatin 5.4 34* *: statistically significant benefit. Summary of lipid intervention trials performed in patients with hypercholesterolemia and coronary heart disease (CHD). Drug therapy lowered the coronary event rate in all studies, although not all of the changes were statistically significant.