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puptodate· P· item f0_54_876

P rednisone. One complete course is given every 21 days. Full treatment usually consists of six to eight such courses. Drug Dose and route [1,2] Given on day(s) Cyclophosphamide 750 mg/m 2 IV Day 1 Doxorubicin 50 mg/m 2 IV Day 1 Vincristine 1.4 mg/m 2 IV (maximum 2 mg) Day 1 Prednisone 100 mg per day orally Days 1 through 5 References: McKelvey EM, Gottlieb JA, Wilson HE, et al. Hydroxyldaunomycin (Adriamycin®) combination chemotherapy in malignant lymphoma. Cancer 1976; 38:1484. Fisher RI, Gaynor ER, Dahlberg S, et al. Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma. N Engl J Med 1993; 328:1002.