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©2013 UpToDate ® Print Email Cytomegalovirus pneumonitis (A, B) High-resolution computed tomography images (1.0 mm collimation) at the levels of the azygos arch (A) and bronchus intermedius (B) show bilateral ground-glass opacities and poorly defined small nodules (arrows). A small right pleural effusion is also present. (C) Photomicrograph of a biopsy specimen shows a moderate degree of interstitial fibrosis and chronic inflammation (white arrow) as well as plugs of fibroblastic tissue in the lumens of several airspaces (black arrows). (D) Highly magnified photomicrograph shows several large cells containing intranuclear inclusions consistent with cytomegalovirus (black arrows). (Compare size with hyperplastic type 2 pneumocytes [white arrow].) The patient was a 28-year-old man with acute myelogenous leukemia. Reproduced with permission from: Muller NL, Fraser RS, Lee KS, Johkoh T. Pulmonary Infection. In: Diseases of the Lung - Radiologic and Pathologic Correlations, Lippincott Williams & Wilkins, Philadelphia, 2003. Copyright © 2003 Lippincott Williams & Wilkins. file://www.lww.com