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©2013 UpToDate ® Print Email Trials of chemotherapy versus chemoradiotherapy followed by chemotherapy in locally advanced pancreatic cancer Au, year 5-FU plus arms n RT dose Outcome Hazel J; 1981 5-FU + methyl-CCNU 15 Median OS 7.8 versus 7.3 months (NSS) RT + 5-FU 500 mg/m 2 weekly Post CRT: 5-FU + methyl-CCNU 15 46 Gy Klaassen D; 1985 5-FU weekly bolus 44 Median OS 8.2 versus 8.3 months (NSS) RT + 5-FU 600 mg/m 2  days 1 to 3 only Post CRT: 5-FU weekly bolus 47 40 Gy GITSG; 1988 5-FU + streptozocin + mitomycin 21 Median OS significantly better with CRT (42 versus 32 weeks) RT + 5-FU 350 mg/m 2 per day, first three + last three days RT Post CRT: 5-FU + streptozocin + mitomycin 22 54 Gy Chauffert B; 2006 Gemcitabine 60 Median OS significantly better with chemotherapy alone (14.3 versus 8.4 months) RT + infus 5-FU + cisplatin days 1 to 5 every week Post CRT: Gemcitabine 59 60 Gy Loehrer P; 2011 Gemcitabine 37 RT plus gemcitabine 34 50.4 Gy Median OS significantly better with CRT (11.1 versus 9.2 months) 5-FU: 5-fluorouracil; CRT: chemoradiotherapy; GITSG: Gastrointestinal Tumor Study Group; OS: overall survival; NSS: differences not statistically significant; RT: radiation therapy.