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©2013 UpToDate ® Print Email Computed tomography studies on detection of cardiac allograft vasculopathy Author, year n Gold standard Sensitivity Specificity Romeo, 2005 [1] 53 Angiography >50 percent stenosis 0.83 0.95 Iyengar, 2006 [2] 20 Angiography >50 pecent stenosis 1/1 detected - Sigurdsson, 2006 [3] 54 Angiography >50 percent stenosis 0.86 0.99 Gregory, 2006 [4] 20 IVUS 0.70 0.92 Pichler, 2008 [5] 66 Angiography >70 percent stenosis 0.59 0.94 Schepis, 2009 [6] 30 IVUS 0.85 0.84 Mastrobuoni, 2009 [7] 30 Angiography* - 0.92 Von Ziegler, 2009 [8] 28 Angiography >50 percent stenosis 0.88 0.97 * Only performed when CT abnormal. References: Romeo, G, Houyel, L, Angel, CY, et al. Coronary stenosis detection by 16-slice computed tomography in heart transplant patients: comparison with conventional angiography and impact on clinical management. J Am Coll Cardiol 2005; 45:1826. Iyengar, S, Feldman, DS, Cooke, GE, et al. Detection of coronary artery disease in orthotopic heart transplant recipients with 64-detector row computed tomography angiography. J Heart Lung Transplant 2006; 25:1363. Sigurdsson, G, Carrascosa, P, Yamani, MH, et al. Detection of transplant coronary artery disease using multidetector computed tomography with adaptative multisegment reconstruction. J Am Coll Cardiol 2006; 48:772. Gregory, SA, Ferencik, M, Achenbach, S, et al. Comparison of sixty-four-slice multidetector computed tomographic coronary angiography to coronary angiography with intravascular ultrasound for the detection of transplant vasculopathy. Am J Cardiol 2006; 98:877. Pichler, P, Loewe, C, Roedler, S, et al. Detection of high-grade stenoses with multislice computed tomography in heart transplant patients. J Heart Lung Transplant 2008; 27:310. Schepis, T, Achenbach, S, Weyand, M, et al. Comparison of dual source computed tomography versus intravascular ultrasound for evaluation of coronary arteries at least one year after cardiac transplantation. Am J Cardiol 2009; 104:1351. Mastrobuoni, S, Bastarrika, G, Ubilla, M, et al. Dual-source CT coronary angiogram in heart transplant recipients in comparison with dobutamine stress echocardiography for detection of cardiac allograft vasculopathy. Transplantation 2009; 87:587.

Schepis, T, Achenbach, S, Weyand, M, et al. Comparison of dual source computed tomography versus intravascular ultrasound for evaluation of coronary arteries at least one year after cardiac transplantation. Am J Cardiol 2009; 104:1351. Mastrobuoni, S, Bastarrika, G, Ubilla, M, et al. Dual-source CT coronary angiogram in heart transplant recipients in comparison with dobutamine stress echocardiography for detection of cardiac allograft vasculopathy. Transplantation 2009; 87:587. von Ziegler, F, Leber, AW, Becker, A, et al. Detection of significant coronary artery stenosis with 64-slice computed tomography in heart transplant recipients: a comparative study with conventional coronary angiography. Int J Cardiovasc Imaging 2009; 25:91. Courtesy of Dr. Finn Gustafsson.