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©2013 UpToDate ® Print Email Triple drug prophylaxis for acute graft-versus-host disease after hematopoietic stem cell transplantation Cyclosporine Day Dose Route -2 to +3 5 mg/kg* IV QD by infusion over 20 hours +4 to +14 3 mg/kg IV QD by infusion over 20 hours +15 to +35 3.75 mg/kg IV QD by infusion over 20 hours +36 to +83 5 mg/kg PO BID +84 to +97 4 mg/kg PO BID +98 to +119 3 mg/kg PO BID +120 to +180 2 mg/kg PO BID Methotrexate• Regimen A Regimen B Day Dose and route Day Dose and route +1 15 mg/m2, IV +1 15 mb/m2, IV +3 10 mg/m2, IV +3 10 mg/m2, IV +6 10 mg/m2, IV +6 10 mg/m2, IV +11 10 mg/m2, IV +11 Placebo Without methylprednisolone Withmethylprednisolone Day Dose and route +7 to +14 0.25 mg/kg IV BID +15 to +28 0.5 mg/kg IV BID +29 to +42 0.4 mg/kg PO BID +43 to +56 0.25 mg/kg PO BID +57 to +119 0.1 mg/kg PO BID +120 to +180 0.1 mg/kg PO QD * Patients receiving a matched unrelated transplant do not receive the loading dose (ie, cyclosporine starts on day -2 at 3 mg/kg IV QD by infusion over 20 hours). • Note the different dosing schedules of methotrexate in the two regimens.