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©2013 UpToDate ® Print Email Cairo-Bishop definition of laboratory tumor lysis syndrome Element Value Change from baseline Uric acid ≥476 micromol/L (8 mg/dL) 25 percent increase Potassium ≥6.0 mmol/L (or 6 mEq/L) 25 percent increase Phosphorus ≥2.1 mmol/L (6.5 mg/dL) for children or ≥1.45 mmol/L (4.5 mg/dL) for adults 25 percent increase Calcium ≤1.75 mmol/L (7 mg/dL) 25 percent decrease NOTE: Two or more laboratory changes within three days before or seven days after cytotoxic therapy. Reproduced with permission from: Coiffier B, Altman A, Pui CH, et al. Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review. J Clin Oncol 2008; 26:2767. Copyright ©2008 American Society of Clinical Oncology. All rights reserved.